Roles of fringe genes and Notch signaling during development. Analysis of cyclic mRNA expression during somitogenesis: linking the Notch pathway and the segmentation clock.
Graduate Students: Emily Shifley, Maurisa Riley, Dustin Williams
Undergraduate Students: Anthony Weston, Tierra Ware, Skye Bochter
Research Technician: Jorge Torres
Moran, J.L., E.T. Shifley, J.M. Levorse, S. Mani, K.Ostmann, Ariadna Perez-Balaguer, D.M. Walker, T.F. Vogt, and S.E. Cole. (2009) Manic fringe is not required for embryonic development, and fringe family members do not exhibit redundant functions in the axial skeleton, limb, or hindbrain. Dev. Dyn. in press.
Shifley, E.T. and S.E. Cole. (2008) Lunatic fringe protein processing by proprotein convertases may contribute to the short protein half-life in the segmentation clock. Biochim Biophys Acta, Mol Cell Res. 1783, 2384-90
McBride, K.L., M.F. Riley, G.A. Zender, S.M. Fitzgerald-Butt, J.A. Towbin, J.W. Belmont and S.E. Cole. (2008) Notch1 mutations in individuals with left ventricular outflow tract malformations reduce ligand-induced signaling. Hum Mol. Gen. 17, 2886-93.
Ryan, M.J., C. Bales, A. Nelson, D.M. Gonzalez, L. Underkoffler, M. Segalov, J. Wilson-Rawls, S. E. Cole, J.L. Moran, P. Russo, N.B. Spinner, K. Kusumi, and K.M. Loomes. (2008) Bile Duct Proliferation in Jag1/Fringe Heterozygous Mice Identifies Candidate Modifiers of the Alagille Syndrome Hepatic Phenotype. Hepatology 48, 1989-1997.
Shifley, E.T., VanHorn, K.M., Perez-Balaguer, A., Franklin, J.D., Weinstein, M. and S.E. Cole. (2008) Oscillatory Lunatic fringe activity is critical for segmentation of the anterior but not posterior skeleton. Development 135: 899-908
Shifley, E.T. and S.E. Cole. (2007) The vertebrate segmentation clock and its role in skeletal birth defects. Birth Defects Res C Embryo Today. 81:121-133.
Cole, S.E., J.M. Levorse, S.M. Tilghman, and T.F. Vogt. (2002). Clock regulatory elements control cyclic expression of Lunatic fringe during somitogenesis. Dev Cell 3: 75-84.
Cole, S.E., M.S. Mao, S.H. Johnston, and T.F. Vogt. (2001) Identification, expression analysis and mapping of B3galt6, a putative galactosyltransferase with similarity to Drosophila brainiac. Mammalian Genome 12:177-179.
Bohne, J., S.E. Cole, C. Sune, B.R. Lindman, V.D. Ko, T.F. Vogt, and M.A. Garcia-Blanco. (2000) Expression analysis and mapping of the mouse and human transcriptional regulator CA150. Mammalian Genome 11:930-933.